Sepsis

What is...

What is sepsis?

Sepsis is a rare, but potentially life-threatening illness that can happen in response to blood infections caused by certain toxin-producing bacteria.

The infection can start anywhere in the body.

The common sites for bacteria to enter the blood stream are the lungs, intestines, urinary tract (kidneys), skin and upper respiratory tract (ears, nose, or throat).

Because the infected blood travels throughout the body, toxins released by the bacteria can affect all the other organ systems in the body. These toxins can cause the body's immune system to overreact and attack itself.

If not treated, sepsis can cause the kidneys, lungs, brain, and other organs to stop working, leading to life-threatening circulatory failure (septic shock).

The most common bacteria that can cause sepsis are Streptococcus pneumoniae (pneumococcus), Neisseria menigitidis (meningococcus), Haemophilus influenzae type b, Salmonella and Staphylococcus aureus.

In newborn babies different types of intestinal bacteria, including E.coli, listeria monocytogenes and Group B streptococcus (GBS) can cause sepsis. Rarely, viral and fungal infections can also trigger sepsis.

Symptoms

Symptoms and signs

Sepsis can occur in the course of another infection and would present with symptoms related to that condition.

The first sign of sepsis may be a fever and just not feeling well. Associated symptoms can include poor appetite, an unusual rash, vomiting, diarrhea, tiredness, irritability, and just not being as active as usual.

An infant who has fever, will not eat, is lethargic, seems irritable, and cries when the parents pick him up to try to comfort him, should be seen by a doctor right away to rule out sepsis.

Infants in the first two months of life may have sepsis without running a fever, and may even have an unusually low body temperature.

Petechiae (small bleeding lesions in the skin) are a warning sign of sepsis, and can be seen with a number of different bacteria, but commonly with infection caused by meningococci.

They are red-purplish in color and can appear anywhere on the skin. When pressure is applied to these skin lesions, either with a glass or a finger, petechiae will still be visible whereas most other rashes would disappear.

Sepsis and meningitis can occur at the same time, especially when the infection is caused by meningococci. The classic symptoms of meningitis are headache, fever, and stiff neck.

Complications

Complications

Sepsis is a life threatening infection with a high death rate.

Immediate treatment with intravenous antibiotics in large doses is absolutely critical.

During sepsis, organs throughout the body are affected. This can lead to circulatory failure (septic shock), respiratory failure, kidney failure, and brain damage.

Uncontrolled bleeding, blood clots, loss of consciousness and death can all occur, unless treatment is started as soon as possible.

Home treatment

Treatment / What you should do

If you fear that your child has sepsis, you must immediately contact a doctor or call an ambulance.

A child with sepsis will need to be admitted to the hospital for intensive treatment, including high doses of antibiotics, intravenous fluids, blood pressure support, and other helpful measures.

Blood tests will be taken to confirm that there are bacteria in the blood. Sometimes, samples of the fluid around the spinal cord (a lumbar puncture) are taken to look for meningitis, along with a urine sample to look for a urine infection.

Contact a doctor immediately, if your infant does not want to eat, has a fever, has difficulty breathing, has poor skin color, seems irritable, or lethargic, or the 'soft spot' on the child's head seems fuller than usual. These all can be signs that your child has a serious infection.

Prevention

Prevention

Some vaccines protect against the bacteria that can lead to sepsis or cause meningitis, such as Haemophilus influenzae (Hob), meningococcus, and pneumococcus.

Four doses of Hib and pneumococcus vaccine are recommended, at 2, 4, 6 and 12-15 months of age and there is also a protective vaccine against certain groups of meningococci bacteria for teenagers.

Pregnant women can be tested for the GBS bacteria before giving birth, so that antibiotics can be given to the mother to reduce the risk of passing the infection to the infant during delivery.

If your child has been diagnosed with a blood infection, it may be necessary to treat other members of the family, or other people with whom the child has close contact, with antibiotics to prevent them from getting the infection or spreading the germ.

The same is true for children who are in daycare with a child with meningococcal disease. Your doctor will determine if this is necessary.

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